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Mouse Sik2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8CFH6 |
| Other Accession | NP_848825.2 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 104198 Da |
| Antigen Region | 606-633 aa |
| Gene ID | 235344 |
|---|---|
| Other Names | Serine/threonine-protein kinase SIK2, Salt-inducible kinase 2, SIK-2, Serine/threonine-protein kinase SNF1-like kinase 2, Sik2, Snf1lk2 |
| Target/Specificity | This Mouse Sik2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 606-633 amino acids from the Central region of mouse Sik2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Sik2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Sik2 |
|---|---|
| Synonyms | Snf1lk2 |
| Function | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:12624099, PubMed:16817901, PubMed:29211348). Phosphorylates 'Ser-794' of IRS1 in insulin- stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction (PubMed:12624099). Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:16817901). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity. In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (By similarity). Also plays a role in thymic T-cell development (PubMed:34732767). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Present in both white and brown adipose tissues with levels increasing during adipocyte differentiation. Lower levels observed in the testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
References
Trivedi, C.M., et al. Dev. Cell 19(3):450-459(2010)
Muraoka, M., et al. Am. J. Physiol. Endocrinol. Metab. 296 (6), E1430-E1439 (2009) :
Du, J., et al. Obesity (Silver Spring) 16(3):531-538(2008)
Katoh, Y., et al. FEBS J. 273(12):2730-2748(2006)
Horike, N., et al. J. Biol. Chem. 278(20):18440-18447(2003)
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