|Application ||WB, E|
|Calculated MW||104198 Da|
|Antigen Region||606-633 aa|
|Other Names||Serine/threonine-protein kinase SIK2, Salt-inducible kinase 2, SIK-2, Serine/threonine-protein kinase SNF1-like kinase 2, Sik2, Snf1lk2|
|Target/Specificity||This Mouse Sik2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 606-633 amino acids from the Central region of mouse Sik2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Sik2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.|
|Tissue Location||Present in both white and brown adipose tissues with levels increasing during adipocyte differentiation Lower levels observed in the testis|
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Provided below are standard protocols that you may find useful for product applications.
Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Trivedi, C.M., et al. Dev. Cell 19(3):450-459(2010)
Muraoka, M., et al. Am. J. Physiol. Endocrinol. Metab. 296 (6), E1430-E1439 (2009) :
Du, J., et al. Obesity (Silver Spring) 16(3):531-538(2008)
Katoh, Y., et al. FEBS J. 273(12):2730-2748(2006)
Horike, N., et al. J. Biol. Chem. 278(20):18440-18447(2003)
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