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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Vrk2 Antibody (C-term)   

Mouse Vrk2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Vrk2 Antibody (C-term) AP17443b
    Mouse Vrk2 Antibody (C-term) (Cat. #AP17443b) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Vrk2 antibody detected the Vrk2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8BN21
Other Accession NP_081536.2
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 58119 Da
Antigen Region 354-381 aa
Additional Information
Gene ID 69922
Other Names Serine/threonine-protein kinase VRK2, Vaccinia-related kinase 2, Vrk2
Target/Specificity This Mouse Vrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-381 amino acids from the C-terminal region of mouse Vrk2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Vrk2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Vrk2
Function Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates histone H3. Phosphorylates 'Thr-18' of p53/TP53, and thereby increases its stability and activity. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. May also phosphorylate MAPK8IP1. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (By similarity).
Cellular Location Cytoplasm. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Mitochondrion membrane; Single-pass type IV membrane protein
Tissue Location Expressed in liver, kidney and muscle. Weakly expressed in thymus, bone marrow and spleen
Research Areas
Citations (0)

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Probable serine/threonine kinase (By similarity).


Bailey, P.J., et al. Exp. Cell Res. 312(16):3108-3119(2006)
Wang, S., et al. PLoS Genet. 2 (2), E15 (2006) :
Nichols, R.J., et al. J. Biol. Chem. 279(9):7934-7946(2004)
Vega, F.M., et al. FEBS Lett. 544 (1-3), 176-180 (2003) :
Agoulnik, A.I., et al. Hum. Mol. Genet. 11(24):3047-3053(2002)

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$ 295.00
$ 99.00
Cat# AP17443b
(40 western blots)
Availability: In Stock
Bulk Size
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