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AP4M1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O00189 |
| Other Accession | Q2PWT8, Q9JKC7, Q29RY8, NP_004713.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49977 Da |
| Antigen Region | 223-251 aa |
| Gene ID | 9179 |
|---|---|
| Other Names | AP-4 complex subunit mu-1, AP-4 adaptor complex mu subunit, Adaptor-related protein complex 4 subunit mu-1, Mu subunit of AP-4, Mu-adaptin-related protein 2, mu-ARP2, Mu4-adaptin, mu4, AP4M1, MUARP2 |
| Target/Specificity | This AP4M1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-251 amino acids from the Central region of human AP4M1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AP4M1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AP4M1 (HGNC:574) |
|---|---|
| Synonyms | MUARP2 |
| Function | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10436028, PubMed:11139587, PubMed:10066790, PubMed:11802162, PubMed:20230749). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (PubMed:11139587, PubMed:20230749). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (By similarity). Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos (PubMed:10436028, PubMed:11139587, PubMed:26544806, PubMed:20230749). The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity). |
| Cellular Location | Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Early endosome. Note=Found in soma and dendritic shafts of neuronal cells. {ECO:0000250|UniProtKB:Q2PWT8} |
| Tissue Location | Ubiquitous. Highly expressed in testis and lowly expressed in brain and lung. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system.
References
Verkerk, A.J., et al. Am. J. Hum. Genet. 85(1):40-52(2009)
Matsuda, S., et al. Neuron 57(5):730-745(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Simmen, T., et al. Nat. Cell Biol. 4(2):154-159(2002)
Boehm, M., et al. EMBO J. 20(22):6265-6276(2001)
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