|Application ||WB, E|
|Other Accession||Q2PWT8, Q9JKC7, Q29RY8, NP_004713.2|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||49977 Da|
|Antigen Region||223-251 aa|
|Other Names||AP-4 complex subunit mu-1, AP-4 adaptor complex mu subunit, Adaptor-related protein complex 4 subunit mu-1, Mu subunit of AP-4, Mu-adaptin-related protein 2, mu-ARP2, Mu4-adaptin, mu4, AP4M1, MUARP2|
|Target/Specificity||This AP4M1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-251 amino acids from the Central region of human AP4M1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AP4M1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the AP-4 complex, a novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal- lysosomal system. Plays a role in the intracellular trafficking of APP from the trans-Golgi network (TGN) to endosomes, and thereby inhibits amyloidogenic processing of APP.|
|Cellular Location||Golgi apparatus, trans-Golgi network. Membrane, coated pit. Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells|
|Tissue Location||Ubiquitous. Highly expressed in testis and lowly expressed in brain and lung.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system.
Verkerk, A.J., et al. Am. J. Hum. Genet. 85(1):40-52(2009)
Matsuda, S., et al. Neuron 57(5):730-745(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Simmen, T., et al. Nat. Cell Biol. 4(2):154-159(2002)
Boehm, M., et al. EMBO J. 20(22):6265-6276(2001)
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