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NKIRAS1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Country
United States
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Ordering Information
Catalog # SizeAvailability Available Date  
AP17459c 400 µl
(40 western blots)
Backorder 4 months
AP17459c-ev 80 µl
(8 western blots)
Backorder 4 months
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NKIRAS1 Antibody (Center) - Product info

Application
  • Applications Legend:
  • WB=Western Blotting
  • IP=Immunoprecipitation
  • IHC-P=Immunohistochemistry (Paraffin)
  • IF-IC=Immunofluorescence (Immunocytochemistry)
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary AccessionQ9NYS0
Other AccessionQ9BH04, NP_065078.1
ReactivityHuman
PredictedMonkey
IsotypeRabbit Ig
Calculated MW21643 Da

NKIRAS1 Antibody (Center) - Additional info

Gene ID 28512
Other Names
NKIRAS1; KBRAS1; NF-kappa-B inhibitor-interacting Ras-like protein 1; I-kappa-B-interacting Ras-like protein 1
Target/Specificity
This NKIRAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-76 amino acids from the Central region of human NKIRAS1.
Dilution
WB~~1:1000
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
NKIRAS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.

NKIRAS1 Antibody (Center) - Protein Information

Name NKIRAS1
Synonyms KBRAS1
Function
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Cellular Location
Cytoplasm.
Tissue Location
Widely expressed.

NKIRAS1 Antibody (Center) - Related products

BP17459c: NKIRAS1 Antibody (Center) Blocking Peptide

AT3054a: NKIRAS1 Antibody (monoclonal) (M01)

NKIRAS1 Antibody (Center) - Research Areas

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BACKGROUND

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP-and GDP-bound forms block phosphorylation of NFKBIB.

REFERENCES

Gerashchenko, G.V., et al. Exp. Oncol. 32(2):71-75(2010)
Dieguez-Gonzalez, R., et al. Ann. Rheum. Dis. 68(4):579-583(2009)
Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
Chen, Y., et al. Mol. Cell. Biol. 24(7):3048-3056(2004)
Chen, Y., et al. J. Biol. Chem. 278(25):23101-23106(2003)