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NKIRAS1 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP17459c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP17459c-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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NKIRAS1 Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | Q9NYS0 |
| Other Accession | Q9BH04, NP_065078.1 |
| Reactivity | Human |
| Predicted | Monkey |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 21643 Da |
NKIRAS1 Antibody (Center) - Additional info | |
| Gene ID 28512 | |
| Other Names NKIRAS1; KBRAS1; NF-kappa-B inhibitor-interacting Ras-like protein 1; I-kappa-B-interacting Ras-like protein 1 | |
| Target/Specificity This NKIRAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-76 amino acids from the Central region of human NKIRAS1. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions NKIRAS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
NKIRAS1 Antibody (Center) - Protein Information | |
| Name NKIRAS1 | |
| Synonyms KBRAS1 | |
| Function Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB | |
| Cellular Location Cytoplasm. | |
| Tissue Location Widely expressed. | |
NKIRAS1 Antibody (Center) - Related products
AP17459c: NKIRAS1 Antibody (Center)
NKIRAS1 Antibody (Center) - Application data
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NKIRAS1 Antibody (Center) (Cat. #AP17459c) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the NKIRAS1 antibody detected the NKIRAS1 protein (arrow).
NKIRAS1 Antibody (Center) - Research Areas
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BACKGROUND
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP-and GDP-bound forms block phosphorylation of NFKBIB.
REFERENCES
Gerashchenko, G.V., et al. Exp. Oncol. 32(2):71-75(2010) Dieguez-Gonzalez, R., et al. Ann. Rheum. Dis. 68(4):579-583(2009) Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005) Chen, Y., et al. Mol. Cell. Biol. 24(7):3048-3056(2004) Chen, Y., et al. J. Biol. Chem. 278(25):23101-23106(2003)
