|Application ||WB, E|
|Other Accession||Q9BH04, NP_065078.1|
|Calculated MW||21643 Da|
|Antigen Region||48-76 aa|
|Other Names||NF-kappa-B inhibitor-interacting Ras-like protein 1, I-kappa-B-interacting Ras-like protein 1, Kappa B-Ras protein 1, KappaB-Ras1, NKIRAS1, KBRAS1|
|Target/Specificity||This NKIRAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-76 amino acids from the Central region of human NKIRAS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NKIRAS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP-and GDP-bound forms block phosphorylation of NFKBIB.
Gerashchenko, G.V., et al. Exp. Oncol. 32(2):71-75(2010)
Dieguez-Gonzalez, R., et al. Ann. Rheum. Dis. 68(4):579-583(2009)
Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
Chen, Y., et al. Mol. Cell. Biol. 24(7):3048-3056(2004)
Chen, Y., et al. J. Biol. Chem. 278(25):23101-23106(2003)
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