|Application ||WB, E|
|Other Accession||Q8K3G9, NP_060641.2|
|Calculated MW||74493 Da|
|Antigen Region||124-152 aa|
|Other Names||DCC-interacting protein 13-beta, Dip13-beta, Adapter protein containing PH domain, PTB domain and leucine zipper motif 2, APPL2, DIP13B|
|Target/Specificity||This APPL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-152 amino acids from the N-terminal region of human APPL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APPL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.|
|Cellular Location||Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF|
|Tissue Location||High levels in brain, heart, kidney and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
Chial, H.J., et al. PLoS ONE 5 (8), E12471 (2010) :
Rashid, S., et al. J. Biol. Chem. 284(27):18115-18128(2009)
Chial, H.J., et al. Traffic 9(2):215-229(2008)
Nechamen, C.A., et al. Mol. Cell. Endocrinol. 260-262, 93-99 (2007) :
Mao, X., et al. Nat. Cell Biol. 8(5):516-523(2006)
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