|Application ||WB, E|
|Other Accession||NP_001159884.1, NP_071421.1|
|Calculated MW||49674 Da|
|Antigen Region||405-431 aa|
|Other Names||SPARC-related modular calcium-binding protein 2, Secreted modular calcium-binding protein 2, SMOC-2, Smooth muscle-associated protein 2, SMAP-2, SMOC2, SMAP2|
|Target/Specificity||This SMOC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 405-431 amino acids from the C-terminal region of human SMOC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SMOC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.|
|Cellular Location||Secreted, extracellular space, extracellular matrix, basement membrane|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Birlea, S.A., et al. J. Invest. Dermatol. 130(3):798-803(2010)
Wilk, J.B., et al. Am. J. Respir. Crit. Care Med. 175(6):554-560(2007)
Rocnik, E.F., et al. J. Biol. Chem. 281(32):22855-22864(2006)
Vannahme, C., et al. Biochem. J. 373 (PT 3), 805-814 (2003) :
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