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SPIRE1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SPIRE1 Antibody (C-term) AP17465b
    SPIRE1 Antibody (C-term) (Cat. #AP17465b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SPIRE1 antibody detected the SPIRE1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q08AE8
Other Accession Q52KF3, Q4R707, NP_001122099.1, NP_001122098.1
Reactivity Human
Predicted Monkey, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 85544 Da
Antigen Region 665-691 aa
Additional Information
Gene ID 56907
Other Names Protein spire homolog 1, Spir-1, SPIRE1 {ECO:0000312|EMBL:AAI252071}, KIAA1135, SPIR1
Target/Specificity This SPIRE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 665-691 amino acids from the C-terminal region of human SPIRE1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSPIRE1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPIRE1 {ECO:0000312|EMBL:AAI25207.1}
Synonyms KIAA1135, SPIR1
Function Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.
Cellular Location Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Punctate spots in perinuclear region and cytoplasm, colocalized with Rab11.
Research Areas
Citations (0)

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Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).[supplied by OMIM].


Rose, J. Phd, et al. Mol. Med. (2010) In press :
Pechlivanis, M., et al. J. Biol. Chem. 284(37):25324-25333(2009)
Bosch, M., et al. Mol. Cell 28(4):555-568(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Kerkhoff, E., et al. Curr. Biol. 11(24):1963-1968(2001)

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$ 295.00
$ 99.00
Cat# AP17465b
(40 western blots)
Availability: In Stock
Bulk Size
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