|Application ||WB, E|
|Other Accession||Q8VEL2, NP_001070993.1, NP_001070994.1|
|Calculated MW||72203 Da|
|Antigen Region||18-45 aa|
|Other Names||Myotubularin-related protein 14, 313-, HCV NS5A-transactivated protein 4 splice variant A-binding protein 1, NS5ATP4ABP1, hJumpy, MTMR14, C3orf29|
|Target/Specificity||This MTMR14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-45 amino acids from the N-terminal region of human MTMR14.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MTMR14 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.|
|Cellular Location||Cytoplasm. Note=Found in reticular structures and plasma membrane ruffles Concentrated near the nucleus|
|Tissue Location||Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with autosomal dominant centronuclear myopathy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 18.
Gibbs, E.M., et al. Autophagy 6(6):819-820(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Vergne, I., et al. EMBO J. 28(15):2244-2258(2009)
Tosch, V., et al. Hum. Mol. Genet. 15(21):3098-3106(2006)
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