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MTMR14 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NCE2 |
| Other Accession | Q8VEL2, NP_001070993.1, NP_001070994.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 72203 Da |
| Antigen Region | 18-45 aa |
| Gene ID | 64419 |
|---|---|
| Other Names | Myotubularin-related protein 14, 313-, HCV NS5A-transactivated protein 4 splice variant A-binding protein 1, NS5ATP4ABP1, hJumpy, MTMR14, C3orf29 |
| Target/Specificity | This MTMR14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-45 amino acids from the N-terminal region of human MTMR14. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MTMR14 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTMR14 |
|---|---|
| Synonyms | C3orf29 |
| Function | Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. |
| Cellular Location | Cytoplasm. Note=Found in reticular structures and plasma membrane ruffles Concentrated near the nucleus |
| Tissue Location | Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with autosomal dominant centronuclear myopathy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 18.
References
Gibbs, E.M., et al. Autophagy 6(6):819-820(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Vergne, I., et al. EMBO J. 28(15):2244-2258(2009)
Tosch, V., et al. Hum. Mol. Genet. 15(21):3098-3106(2006)
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