OSBPL6 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9BZF3 |
Other Accession | NP_665682.1, NP_115912.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 106306 Da |
Antigen Region | 769-796 aa |
Gene ID | 114880 |
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Other Names | Oxysterol-binding protein-related protein 6, ORP-6, OSBP-related protein 6, OSBPL6, ORP6 |
Target/Specificity | This OSBPL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 769-796 amino acids from the C-terminal region of human OSBPL6. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | OSBPL6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | OSBPL6 |
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Synonyms | ORP6 |
Function | Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). |
Cellular Location | Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus envelope. Cell membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum {ECO:0000250|UniProtKB:Q8BXR9} |
Tissue Location | Expressed in brain and striated muscle (at protein level) (PubMed:14593528). Widely expressed (PubMed:11735225). Expressed in skeletal muscle (PubMed:14593528) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.
References
Maestrini, E., et al. Mol. Psychiatry 15(9):954-968(2010)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Lehto, M., et al. Cell Tissue Res. 315(1):39-57(2004)
Jaworski, C.J., et al. Genomics 78(3):185-196(2001)
Lehto, M., et al. J. Lipid Res. 42(8):1203-1213(2001)
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