|Application ||WB, E|
|Other Accession||NP_665682.1, NP_115912.1|
|Calculated MW||106306 Da|
|Antigen Region||769-796 aa|
|Other Names||Oxysterol-binding protein-related protein 6, ORP-6, OSBP-related protein 6, OSBPL6, ORP6|
|Target/Specificity||This OSBPL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 769-796 amino acids from the C-terminal region of human OSBPL6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OSBPL6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Weakly binds 25-hydroxycholesterol.|
|Cellular Location||Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus envelope Cell membrane; Peripheral membrane protein|
|Tissue Location||Expressed in brain and striated muscle (at protein level) (PubMed:14593528). Widely expressed (PubMed:11735225). Expressed in skeletal muscle (PubMed:14593528)|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.
Maestrini, E., et al. Mol. Psychiatry 15(9):954-968(2010)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Lehto, M., et al. Cell Tissue Res. 315(1):39-57(2004)
Jaworski, C.J., et al. Genomics 78(3):185-196(2001)
Lehto, M., et al. J. Lipid Res. 42(8):1203-1213(2001)
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