|Application ||WB, E|
|Other Accession||Q5FWT7, Q8BGR9, Q2KJD7, NP_659486.2|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||36805 Da|
|Antigen Region||222-248 aa|
|Other Names||Ubiquitin-like domain-containing CTD phosphatase 1, Nuclear proteasome inhibitor UBLCP1, UBLCP1|
|Target/Specificity||This UBLCP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-248 amino acids from the C-terminal region of human UBLCP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UBLCP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.|
|Cellular Location||Nucleus. Note=Colocalizes with nuclear proteasomes|
|Tissue Location||Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumor tissues|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
UBLCP1 may specifically dephosphorylate 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit.
Nair, R.P., et al. Nat. Genet. 41(2):199-204(2009)
Zheng, H., et al. Biochem. Biophys. Res. Commun. 331(4):1401-1407(2005)
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