|Application ||WB, E|
|Other Accession||Q7TQ33, NP_001012779.2|
|Calculated MW||47547 Da|
|Antigen Region||380-407 aa|
|Other Names||RGM domain family member B, DRG11-responsive axonal guidance and outgrowth of neurite, DRAGON, RGMB|
|Target/Specificity||This RGMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-407 amino acids from the C-terminal region of human RGMB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RGMB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft|
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Provided below are standard protocols that you may find useful for product applications.
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).
Samad, T.A., et al. J. Biol. Chem. 280(14):14122-14129(2005)
Samad, T.A., et al. J. Neurosci. 24(8):2027-2036(2004)
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