|Application ||WB, E|
|Other Accession||NP_001006641.1, NP_001006640.1|
|Calculated MW||18354 Da|
|Antigen Region||1-30 aa|
|Other Names||Transcription elongation factor A protein-like 1, TCEA-like protein 1, Nuclear phosphoprotein p21/SIIR, Transcription elongation factor S-II protein-like 1, TCEAL1, SIIR|
|Target/Specificity||This TCEAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TCEAL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TCEAL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.|
|Tissue Location||Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen. Expressed in several cancer cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform.
Chung, C.J., et al. Toxicol. Appl. Pharmacol. 232(2):203-209(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Lee, Y.L., et al. J. Lab. Clin. Med. 147(5):228-233(2006)
Santos, A.M., et al. Eur. J. Cancer 42(7):958-963(2006)
Santos, A.M., et al. Biochem. Biophys. Res. Commun. 340(1):256-262(2006)
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