|Application ||WB, E|
|Other Accession||NP_037375.2, NP_001158729.1|
|Calculated MW||53005 Da|
|Antigen Region||378-406 aa|
|Other Names||Secretogranin-3, Secretogranin III, SgIII, SCG3|
|Target/Specificity||This SCG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 378-406 amino acids from the C-terminal region of human SCG3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SCG3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein Secreted. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts in intragranular conditions (By similarity). Neuroendocrine and endocrine secretory granules.|
|Tissue Location||Expressed in brain, heart, kidney, liver and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene.
Li, X., et al. J. Allergy Clin. Immunol. 125(2):328-335(2010)
He, C., et al. Clin. Chim. Acta 402 (1-2), 102-106 (2009) :
Stridsberg, M., et al. Regul. Pept. 148 (1-3), 95-98 (2008) :
Tanabe, A., et al. J. Clin. Endocrinol. Metab. 92(3):1145-1154(2007)
Sakai, Y., et al. Arch. Histol. Cytol. 67(1):57-64(2004)
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