|Application ||WB, E|
|Other Accession||Q1WIM2, Q8BLQ9, NP_001161146.1, NP_001161147.1|
|Calculated MW||47554 Da|
|Antigen Region||50-76 aa|
|Other Names||Cell adhesion molecule 2, Immunoglobulin superfamily member 4D, IgSF4D, Nectin-like protein 3, NECL-3, Synaptic cell adhesion molecule 2, SynCAM 2, CADM2, IGSF4D, NECL3|
|Target/Specificity||This CADM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-76 amino acids from the N-terminal region of human CADM2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CADM2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Cell junction, synapse. Cell projection, axon. Note=Found in the axoplasm of myelinated axons|
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Provided below are standard protocols that you may find useful for product applications.
Members of the large immunoglobulin (Ig) superfamily, such as IGSF4D, have diverse roles in extracellular recognition and intercellular adhesion (Biederer, 2006 [PubMed 16311015]).[supplied by OMIM].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Festen, E.A., et al. Am. J. Gastroenterol. 105(2):395-402(2010)
Biederer, T. Genomics 87(1):139-150(2006)
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