|Application ||WB, E|
|Calculated MW||25301 Da|
|Antigen Region||178-205 aa|
|Other Names||Carbonyl reductase family member 4, 1---, 3-oxoacyl-[acyl-carrier-protein] reductase, 111-, Quinone reductase CBR4, CBR4|
|Target/Specificity||This CBR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 178-205 amino acids from the C-terminal region of human CBR4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CBR4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The heterotetramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (PubMed:19000905). Both homotetramer and the heterotetramer have broad substrate specificity and can reduce 9,10- phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508).|
|Cellular Location||Mitochondrion matrix|
|Tissue Location||Detected in liver and kidney (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
The heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).
Chen, Z., et al. FASEB J. 23(11):3682-3691(2009)
Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) :
Endo, S., et al. Biochem. Biophys. Res. Commun. 377(4):1326-1330(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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