CDC20B Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q86Y33 |
Other Accession | NP_001163873.1, NP_001139206.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 57335 Da |
Antigen Region | 11-39 aa |
Gene ID | 166979 |
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Other Names | Cell division cycle protein 20 homolog B, CDC20B |
Target/Specificity | This CDC20B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 amino acids from the N-terminal region of human CDC20B. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CDC20B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CDC20B (HGNC:24222) |
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Function | Protein regulator of centriole-deuterosome disengagement and subsequently participates in the ciliogenesis in multiciliated cells (MCCs). |
Cellular Location | Cytoplasm. Note=Tightly associated to mature deuterosomes. |
Tissue Location | Expressed in multiciliated cells (MCCs). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The timely destruction of key regulators through ubiquitin-mediated proteolysis ensures the orderly progression of the cell cycle. The APC (anaphase-promoting complex) is a major component of this degradation machinery and its activation is required for the execution of critical events. CDC20B has been implicated as a meiosis specific activator of APC and is required for sporulation in budding yeast.
References
Kimura, K., et al. Genome Res. 16(1):55-65(2006)
Ota, T., et al. Nat. Genet. 36(1):40-45(2004)
Strausberg, R.L., et al. Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903(2002)
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