|Application ||WB, E|
|Calculated MW||24704 Da|
|Antigen Region||126-153 aa|
|Other Names||C-type lectin domain family 4 member D, C-type lectin superfamily member 8, C-type lectin-like receptor 6, CLEC-6, CLEC4D, CLECSF8, MCL|
|Target/Specificity||This CLEC4D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-153 amino acids from the Central region of human CLEC4D.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLEC4D Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
Flornes, L.M., et al. Immunogenetics 56(7):506-517(2004)
Arce, I., et al. Eur. J. Immunol. 34(1):210-220(2004)
Ebner, S., et al. Proteins 53(1):44-55(2003)
Drickamer, K. Curr. Opin. Struct. Biol. 9(5):585-590(1999)
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