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CLEC4D Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WXI8 |
| Other Accession | NP_525126.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24704 Da |
| Antigen Region | 126-153 aa |
| Gene ID | 338339 |
|---|---|
| Other Names | C-type lectin domain family 4 member D, C-type lectin superfamily member 8, C-type lectin-like receptor 6, CLEC-6, CLEC4D, CLECSF8, MCL |
| Target/Specificity | This CLEC4D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-153 amino acids from the Central region of human CLEC4D. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLEC4D Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLEC4D (HGNC:14554) |
|---|---|
| Function | Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage- associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:23602766, PubMed:23911656). The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (PubMed:23602766, PubMed:23911656). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T- helper 17 cell subtypes (PubMed:23602766, PubMed:23911656). The heterodimer formed with CLEC6A is active against fungal infection (PubMed:23911656). Functions as an endocytic receptor (PubMed:14971047). May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (PubMed:14971047). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
References
Flornes, L.M., et al. Immunogenetics 56(7):506-517(2004)
Arce, I., et al. Eur. J. Immunol. 34(1):210-220(2004)
Ebner, S., et al. Proteins 53(1):44-55(2003)
Drickamer, K. Curr. Opin. Struct. Biol. 9(5):585-590(1999)
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