|Application ||WB, E|
|Other Accession||D0Q0Y7, Q6ZWS4, NP_689708.1|
|Calculated MW||18976 Da|
|Antigen Region||17-44 aa|
|Other Names||Protein cornichon homolog 3, CNIH-3, Cornichon family AMPA receptor auxiliary protein 3, CNIH3|
|Target/Specificity||This CNIH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-44 amino acids from the N-terminal region of human CNIH3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNIH3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells).|
|Tissue Location||Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CNIH3 is a member of the cornichon family.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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