|Application ||WB, E|
|Other Accession||D0Q0Y7, Q6ZWS4, NP_689708.1|
|Calculated MW||18976 Da|
|Antigen Region||17-44 aa|
|Other Names||Protein cornichon homolog 3, CNIH-3, Cornichon family AMPA receptor auxiliary protein 3, CNIH3|
|Target/Specificity||This CNIH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-44 amino acids from the N-terminal region of human CNIH3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNIH3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells).|
|Tissue Location||Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).|
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Provided below are standard protocols that you may find useful for product applications.
CNIH3 is a member of the cornichon family.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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