|Application ||WB, E|
|Other Accession||Q0PHV7, NP_659493.2|
|Calculated MW||64949 Da|
|Antigen Region||139-165 aa|
|Other Names||Dapper homolog 3, Antagonist of beta-catenin Dapper homolog 3, Arginine-rich region 1 protein, Dapper antagonist of catenin 3, DACT3, RRR1|
|Target/Specificity||This DACT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 139-165 amino acids from the N-terminal region of human DACT3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DACT3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.|
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Provided below are standard protocols that you may find useful for product applications.
Dact3 is the gene product of the third discovered member of the Dact (Dapper) family of developmentally-expressed genes. Discovered in mouse, a highly conserved ortholog also exists in the human genome. As with other Dact family members, Dact3 may play a role in antagonism of Wnt signaling.
Jiang, X., et al. Cancer Cell 13(6):529-541(2008)
Fisher, D.A., et al. Dev. Dyn. 235(9):2620-2630(2006)
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