|Application ||WB, E|
|Calculated MW||21740 Da|
|Antigen Region||7-34 aa|
|Other Names||DNA damage-inducible transcript 4-like protein, HIF-1 responsive protein RTP801-like, Protein regulated in development and DNA damage response 2, REDD-2, DDIT4L, REDD2, RTP801L|
|Target/Specificity||This DDIT4L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-34 amino acids from the N-terminal region of human DDIT4L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DDIT4L Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.|
|Tissue Location||Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery|
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Provided below are standard protocols that you may find useful for product applications.
DDIT4L inhibits cell growth by regulating the FRAP1 pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.
Koga, Y., et al. Genome Res. 19(8):1462-1470(2009)
Imen, J.S., et al. Free Radic. Biol. Med. 46(10):1404-1410(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Corradetti, M.N., et al. J. Biol. Chem. 280(11):9769-9772(2005)
Cuaz-Perolin, C., et al. Arterioscler. Thromb. Vasc. Biol. 24(10):1830-1835(2004)
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