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ERP27 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96DN0 |
| Other Accession | NP_689534.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 30480 Da |
| Antigen Region | 246-272 aa |
| Gene ID | 121506 |
|---|---|
| Other Names | Endoplasmic reticulum resident protein 27, ER protein 27, ERp27, ERP27, C12orf46 |
| Target/Specificity | This ERP27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 246-272 amino acids from the C-terminal region of human ERP27. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ERP27 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ERP27 |
|---|---|
| Synonyms | C12orf46 |
| Function | Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates (PubMed:16940051, PubMed:23192347). Binds protein substrates via a hydrophobic pocket in the C-terminal domain (PubMed:16940051, PubMed:23192347). May play a role in the unfolded stress response (PubMed:23192347). |
| Cellular Location | Endoplasmic reticulum lumen |
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Provided below are standard protocols that you may find useful for product applications.
Background
ERP27 is a noncatalytic member of the protein disulfide isomerase (PDI; see MIM 608012) family of endoplasmic reticulum (ER) proteins (Alanen et al., 2006 [PubMed 16940051]).[supplied by OMIM].
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Alanen, H.I., et al. J. Biol. Chem. 281(44):33727-33738(2006)
Lim, J., et al. Cell 125(4):801-814(2006)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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