|Application ||WB, E|
|Calculated MW||34588 Da|
|Antigen Region||245-272 aa|
|Other Names||F-box only protein 16, FBXO16, FBX16|
|Target/Specificity||This FBXO16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-272 amino acids from the C-terminal region of human FBXO16.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBXO16 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.|
|Tissue Location||Expressed in heart, spleen and colon.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class.
Cheng, H., et al. Mol. Cells 14(1):56-59(2002)
Cenciarelli, C., et al. Curr. Biol. 9(20):1177-1179(1999)
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