UBE2Q1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q7Z7E8 |
Other Accession | NP_060052.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 46127 Da |
Antigen Region | 78-104 aa |
Gene ID | 55585 |
---|---|
Other Names | Ubiquitin-conjugating enzyme E2 Q1, Protein NICE-5, Ubiquitin carrier protein Q1, Ubiquitin-protein ligase Q1, UBE2Q1, NICE5, UBE2Q |
Target/Specificity | This UBE2Q1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-104 amino acids from the N-terminal region of human UBE2Q1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | UBE2Q1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | UBE2Q1 |
---|---|
Synonyms | NICE5, UBE2Q |
Function | Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:22496338). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q7TSS2}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q7TSS2}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q7TSS2} |
Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to the mouse counterpart.
References
Wassler, M.J., et al. Stem Cells 26(8):2006-2018(2008)
Grelle, G., et al. Mol. Cell Proteomics 5(2):234-244(2006)
Wistow, G., et al. Mol. Vis. 8, 205-220 (2002) :
Marenholz, I., et al. Genome Res. 11(3):341-355(2001)
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