|Application ||WB, E|
|Calculated MW||76632 Da|
|Antigen Region||539-567 aa|
|Other Names||Protein-glutamine gamma-glutamyltransferase E, Transglutaminase E, TG(E), TGE, TGase E, Transglutaminase-3, TGase-3, Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain, Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain, TGM3|
|Target/Specificity||This TGM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 539-567 amino acids from the C-terminal region of human TGM3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TGM3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross- linking structural proteins to hardening the inner root sheath.|
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Provided below are standard protocols that you may find useful for product applications.
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle.
Yamane, A., et al. FEBS J. 277(17):3564-3574(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Negishi, A., et al. Cancer Sci. 100(9):1605-1611(2009)
Fujimoto, A., et al. J. Hum. Genet. 54(8):461-465(2009)
Uemura, N., et al. Int. J. Cancer 124(9):2106-2115(2009)
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