ZBTB4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9P1Z0 |
Other Accession | NP_001122305.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 105114 Da |
Antigen Region | 401-430 aa |
Gene ID | 57659 |
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Other Names | Zinc finger and BTB domain-containing protein 4, KAISO-like zinc finger protein 1, KAISO-L1, ZBTB4, KIAA1538 |
Target/Specificity | This ZBTB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from the Central region of human ZBTB4. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ZBTB4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZBTB4 |
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Synonyms | KIAA1538 |
Function | Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self- renewal (By similarity). |
Cellular Location | Nucleus. Chromosome. Note=Localizes to chromocenters |
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Provided below are standard protocols that you may find useful for product applications.
Background
ZBTB4 may be involved in transcriptional regulation.
References
Sasai, N., et al. Nucleic Acids Res. 38(15):5015-5022(2010)
Yamada, D., et al. Oncogene 28(27):2535-2544(2009)
Weber, A., et al. EMBO J. 27(11):1563-1574(2008)
Filion, G.J., et al. Mol. Cell. Biol. 26(1):169-181(2006)
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