|Application ||WB, E|
|Calculated MW||105114 Da|
|Antigen Region||401-430 aa|
|Other Names||Zinc finger and BTB domain-containing protein 4, KAISO-like zinc finger protein 1, KAISO-L1, ZBTB4, KIAA1538|
|Target/Specificity||This ZBTB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from the Central region of human ZBTB4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZBTB4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688).|
|Cellular Location||Nucleus. Chromosome. Note=Localizes to chromocenters.|
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Provided below are standard protocols that you may find useful for product applications.
ZBTB4 may be involved in transcriptional regulation.
Sasai, N., et al. Nucleic Acids Res. 38(15):5015-5022(2010)
Yamada, D., et al. Oncogene 28(27):2535-2544(2009)
Weber, A., et al. EMBO J. 27(11):1563-1574(2008)
Filion, G.J., et al. Mol. Cell. Biol. 26(1):169-181(2006)
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