TPM2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P07951 |
Other Accession | P58775, P58776, P58774, P19352, Q5KR48, NP_998839.1 |
Reactivity | Human |
Predicted | Bovine, Chicken, Mouse, Rabbit, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 32851 Da |
Antigen Region | 252-280 aa |
Gene ID | 7169 |
---|---|
Other Names | Tropomyosin beta chain, Beta-tropomyosin, Tropomyosin-2, TPM2, TMSB |
Target/Specificity | This TPM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-280 amino acids from the C-terminal region of human TPM2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TPM2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TPM2 |
---|---|
Synonyms | TMSB |
Function | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. |
Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P58775}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P58775} |
Tissue Location | Present in primary breast cancer tissue, absent from normal breast tissue. {ECO:0000269|Ref.10} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Martins-de-Souza, D., et al. J Psychiatr Res 44(14):989-991(2010)
Assinder, S.J., et al. Mol. Carcinog. 49(6):525-531(2010)
Ochala, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9807-9812(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.