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TPM2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TPM2 Antibody (C-term) AP17546b
    TPM2 Antibody (C-term) (Cat. #AP17546b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the TPM2 antibody detected the TPM2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07951
Other Accession P58775, P58776, P58774, P19352, Q5KR48, NP_998839.1
Reactivity Human
Predicted Bovine, Chicken, Mouse, Rabbit, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 32851 Da
Antigen Region 252-280 aa
Additional Information
Gene ID 7169
Other Names Tropomyosin beta chain, Beta-tropomyosin, Tropomyosin-2, TPM2, TMSB
Target/Specificity This TPM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-280 amino acids from the C-terminal region of human TPM2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTPM2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TPM2
Synonyms TMSB
Function Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity).
Cellular Location Cytoplasm, cytoskeleton.
Tissue Location Present in primary breast cancer tissue, absent from normal breast tissue. {ECO:0000269|Ref.10}
Research Areas
Citations (0)

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This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Martins-de-Souza, D., et al. J Psychiatr Res 44(14):989-991(2010)
Assinder, S.J., et al. Mol. Carcinog. 49(6):525-531(2010)
Ochala, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9807-9812(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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Cat# AP17546b
(40 western blots)
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