GLB1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P16278 |
Other Accession | Q60HF6, NP_000395.2, NP_001073279.1 |
Reactivity | Human |
Predicted | Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 76075 Da |
Antigen Region | 81-109 aa |
Gene ID | 2720 |
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Other Names | Beta-galactosidase, Acid beta-galactosidase, Lactase, Elastin receptor 1, GLB1, ELNR1 |
Target/Specificity | This GLB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the N-terminal region of human GLB1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GLB1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GLB1 |
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Synonyms | ELNR1 |
Function | [Isoform 1]: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. |
Cellular Location | [Isoform 1]: Lysosome |
Tissue Location | Detected in placenta (at protein level) (PubMed:8383699). Detected in fibroblasts and testis (PubMed:2511208) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes beta-galactosidase-1, a lysosomal enzyme that hydrolyzes the terminal beta-galactose from ganglioside substrates and other glycoconjugates. Defects in this gene are the cause of GM1-gangliosidosis and Morquio B syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Antonicelli, F., et al. Wound Repair Regen 17(5):631-638(2009)
Hofer, D., et al. Hum. Mutat. 30(8):1214-1221(2009)
Mayer, F.Q., et al. Mol. Genet. Metab. 96 (3), 148 (2009) :
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