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GLDN Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GLDN Antibody (Center) AP17551c
    GLDN Antibody (Center) (Cat. #AP17551c) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GLDN antibody detected the GLDN protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q6ZMI3
Other Accession NP_861454.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 58957 Da
Antigen Region 271-299 aa
Additional Information
Gene ID 342035
Other Names Gliomedin, GLDN, COLM
Target/Specificity This GLDN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-299 amino acids from the Central region of human GLDN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGLDN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GLDN
Synonyms COLM
Function Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q80WL1}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q80WL1}. Note=Detected at the nodes of Ranvier. Detected at immature heminodes {ECO:0000250|UniProtKB:Q80WL1}
Tissue Location Specifically expressed in spinal cord, brain, placenta and sciatic nerve. More abundant in peripheral than central nervous system.
Research Areas
Citations (0)

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Background

GLDN plays a role in the formation of the nodes of Ranvier along myelinated axons. Probable NRCAM and NFASC/neurofascin ligand which may provide a glial positional clue required for the proper molecular assembly of the nodes of Ranvier (By similarity).

References

Eshed, Y., et al. Neuron 47(2):215-229(2005)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Graveel, C.R., et al. Oncogene 22(11):1730-1736(2003)

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$ 295.00
$ 99.00
Cat# AP17551c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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