|Application ||WB, E|
|Other Accession||Q5GFD8, NP_060909.1|
|Calculated MW||36476 Da|
|Antigen Region||1-30 aa|
|Other Names||Protein IMPACT, Imprinted and ancient gene protein homolog, IMPACT|
|Target/Specificity||This IMPACT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human IMPACT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IMPACT Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (By similarity). Through its action on GCN2, may also facilitate neuritogenesis (By similarity).|
|Cellular Location||Cytoplasm. Note=May be associated with polysomes.|
|Tissue Location||Widely expressed. Expressed at high level in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity).
Habibi, D., et al. J. Cell. Physiol. 225(1):196-205(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Pereira, C.M., et al. J. Biol. Chem. 280(31):28316-28323(2005)
Okamura, K., et al. Biochem. Biophys. Res. Commun. 329(3):824-830(2005)
Okamura, K., et al. DNA Res. 11(6):381-390(2004)
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