|Application ||WB, E|
|Other Accession||Q8QZT4, NP_631900.1, NP_777377.1|
|Calculated MW||12854 Da|
|Antigen Region||67-95 aa|
|Other Names||Protein crumbs homolog 3, CRB3|
|Target/Specificity||This CRB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-95 amino acids from the Central region of human CRB3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CRB3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions.|
|Cellular Location||Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells|
|Tissue Location||Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
Pardossi-Piquard, R., et al. Biochemistry 46(48):13704-13710(2007)
Fan, S., et al. J. Cell Biol. 178(3):387-398(2007)
Fogg, V.C., et al. J. Cell. Sci. 118 (PT 13), 2859-2869 (2005) :
Lemmers, C., et al. Mol. Biol. Cell 15(3):1324-1333(2004)
Roh, M.H., et al. J. Cell. Sci. 116 (PT 14), 2895-2906 (2003) :
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