|Application ||WB, E|
|Other Accession||Q91ZR3, NP_001034707.1|
|Calculated MW||37134 Da|
|Antigen Region||280-309 aa|
|Other Names||CREB/ATF bZIP transcription factor, Host cell factor-binding transcription factor Zhangfei, HCF-binding transcription factor Zhangfei, CREBZF, ZF|
|Target/Specificity||This CREBZF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human CREBZF.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CREBZF Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1- dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.|
|Cellular Location||Nucleus. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1|
|Tissue Location||In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver.|
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Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.
Xie, Y.B., et al. J. Biol. Chem. 284(42):28762-28774(2009)
Valderrama, X., et al. J. Neurooncol. 91(1):7-17(2009)
Xie, Y.B., et al. Biochem. J. 416(3):463-473(2008)
Valderrama, X., et al. J. Neurovirol. 14(5):425-436(2008)
Hogan, M.R., et al. FEBS Lett. 580(1):58-62(2006)
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