|Application ||WB, E|
|Calculated MW||107748 Da|
|Antigen Region||349-377 aa|
|Other Names||ALS2 C-terminal-like protein, ALS2CL|
|Target/Specificity||This ALS2CL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-377 amino acids from the Central region of human ALS2CL.|
|Precautions||ALS2CL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.|
|Cellular Location||Cytoplasm. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells|
|Tissue Location||Expressed in heart and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
ALS2CL acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.
Suzuki-Utsunomiya, K., et al. Biochem. Biophys. Res. Commun. 354(2):491-497(2007)
Hadano, S., et al. FEBS Lett. 575 (1-3), 64-70 (2004) :
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