ALS2CL Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q60I27 |
Other Accession | NP_001177636.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 107748 Da |
Antigen Region | 349-377 aa |
Gene ID | 259173 |
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Other Names | ALS2 C-terminal-like protein, ALS2CL |
Target/Specificity | This ALS2CL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-377 amino acids from the Central region of human ALS2CL. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ALS2CL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ALS2CL |
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Function | Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. |
Cellular Location | Cytoplasm. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells |
Tissue Location | Expressed in heart and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ALS2CL acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.
References
Suzuki-Utsunomiya, K., et al. Biochem. Biophys. Res. Commun. 354(2):491-497(2007)
Hadano, S., et al. FEBS Lett. 575 (1-3), 64-70 (2004) :
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