LARP4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q71RC2 |
Other Accession | NP_001164279.1 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 80596 Da |
Antigen Region | 689-717 aa |
Gene ID | 113251 |
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Other Names | La-related protein 4, La ribonucleoprotein domain family member 4, LARP4 |
Target/Specificity | This LARP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 689-717 amino acids from the C-terminal region of human LARP4. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | LARP4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LARP4 |
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Function | RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). |
Cellular Location | Cytoplasm, Stress granule. Cytoplasm, cytosol Note=Localized throughout the cytosol. Partially localized in stress granules in response to arsenite treatment |
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Provided below are standard protocols that you may find useful for product applications.
Background
LARP4 contains one HTH La-type RNA-binding domain and one RRM (RNA recognition motif) domain. There are four named isoforms.
References
Puigdecanet, E., et al. Cancer Genet. Cytogenet. 167(1):39-42(2006)
Kralovics, R., et al. Blood Rev. 19(1):1-13(2005)
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