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NOSIP Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NOSIP Antibody (N-term) AP17578a
    NOSIP Antibody (N-term) (Cat. #AP17578a) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the NOSIP antibody detected the NOSIP protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y314
Other Accession Q4R7H4, NP_057037.1
Reactivity Human
Predicted Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 33172 Da
Antigen Region 67-95 aa
Additional Information
Gene ID 51070
Other Names Nitric oxide synthase-interacting protein, eNOS-interacting protein, NOSIP
Target/Specificity This NOSIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-95 amino acids from the N-terminal region of human NOSIP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNOSIP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOSIP
Function E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813).
Cellular Location Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813)
Tissue Location Expressed in heart, brain and lung. Present in endothelial cells (at protein level).
Research Areas
Citations (0)
citation

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Background

NOSIP negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.

References

Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Schleicher, M., et al. Mol. Cell. Biol. 25(18):8251-8258(2005)
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
Dreyer, J., et al. J. Neurosci. 24(46):10454-10465(2004)

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$ 182.50
$ 70.00
Cat# AP17578a
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