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MYBL1 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MYBL1 Antibody (Center) AP17588C
    MYBL1 Antibody (Center) (Cat. #AP17588c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MYBL1 antibody detected the MYBL1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P10243
Other Accession NP_001073885.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 85887 Da
Antigen Region 510-536 aa
Additional Information
Gene ID 4603
Other Names Myb-related protein A, A-Myb, Myb-like protein 1, MYBL1, AMYB
Target/Specificity This MYBL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 510-536 amino acids from the Central region of human MYBL1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMYBL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYBL1
Synonyms AMYB
Function Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:P51960}.
Tissue Location Expressed in a variety of lymphoid and solid tumor lines cultured in vitro
Research Areas
Citations (0)
citation

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Background

Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.

References

Takahashi, T., et al. FEBS Lett. 358(1):89-96(1995)
Ma, X.P., et al. Cancer Res. 54(24):6512-6516(1994)
Golay, J., et al. Oncogene 9(9):2469-2479(1994)
Barletta, C., et al. Cancer Res. 51(14):3821-3824(1991)
Nomura, N., et al. Nucleic Acids Res. 16(23):11075-11089(1988)

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$ 182.50
$ 70.00
Cat# AP17588C
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