|Application ||WB, E|
|Calculated MW||32179 Da|
|Antigen Region||28-54 aa|
|Other Names||Splicing regulator RBM11, RNA-binding motif protein 11, RBM11|
|Target/Specificity||This RBM11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-54 amino acids from the N-terminal region of human RBM11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RBM11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.|
|Cellular Location||Nucleus, nucleoplasm. Nucleus speckle. Note=Enriched in SRSF2-containing splicing speckles; shuttles between nucleoplasm and speckles|
|Tissue Location||Expressed in brain, hippocampus, prefrontal cortex, cerebellum, spinal cord, testis, mammary gland, spleen and kidney. Also expressed in fetal brain|
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Provided below are standard protocols that you may find useful for product applications.
RBM11, also known as RNA binding motif protein 11, is a human gene. 2 isoforms of the human protein are produced by alternative splicing.
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
Lim, J., et al. Cell 125(4):801-814(2006)
Brun, M.E., et al. Gene 312, 41-50 (2003) :
Gardiner, K., et al. Genomics 79(6):833-843(2002)
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