|Application ||WB, E|
|Other Accession||NP_689408.1, NP_116260.2|
|Calculated MW||46092 Da|
|Antigen Region||387-413 aa|
|Other Names||Tumor necrosis factor receptor superfamily member 19L, Receptor expressed in lymphoid tissues, RELT, TNFRSF19L|
|Target/Specificity||This RELT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-413 amino acids from the C-terminal region of human RELT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RELT Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates activation of NF-kappa-B. May play a role in T- cell activation.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Cytoplasm|
|Tissue Location||Highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver Very low levels in skeletal muscle, testis and colon. Not detected in brain, kidney and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
Cusick, J.K., et al. Cell. Immunol. 261(1):1-8(2010)
Polek, T.C., et al. Biochem. Biophys. Res. Commun. 349(3):1016-1024(2006)
Bossen, C., et al. J. Biol. Chem. 281(20):13964-13971(2006)
Cusick, J.K., et al. Biochem. Biophys. Res. Commun. 340(2):535-543(2006)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
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