|Application ||WB, E|
|Other Accession||Q32LN5, NP_057355.2|
|Calculated MW||28193 Da|
|Antigen Region||76-103 aa|
|Other Names||E3 ubiquitin-protein ligase RNF138, 632-, Nemo-like kinase-associated RING finger protein, NLK-associated RING finger protein, hNARF, RING finger protein 138, RNF138, NARF|
|Target/Specificity||This RNF138 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the Central region of human RNF138.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RNF138 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Yamada, M., et al. J. Biol. Chem. 281(30):20749-20760(2006)
Lim, J., et al. Cell 125(4):801-814(2006)
Saurin, A.J., et al. Trends Biochem. Sci. 21(6):208-214(1996)
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