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RPL10L Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96L21 |
| Other Accession | Q6PDV7, Q29195, Q6ZWV3, Q4R7Y2, P27635, Q09533, Q9XSI3, P86048, Q4R4D3, Q2TBW8, NP_542784.1, A8D8X1, B7NZQ2 |
| Reactivity | Human |
| Predicted | Bovine, Monkey, Mouse, C.Elegans, Pig, Rabbit, Rat, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24519 Da |
| Antigen Region | 9-35 aa |
| Gene ID | 140801 |
|---|---|
| Other Names | 60S ribosomal protein L10-like, RPL10L |
| Target/Specificity | This RPL10L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-35 amino acids from the N-terminal region of human RPL10L. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RPL10L Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RPL10L {ECO:0000303|PubMed:12490704, ECO:0000312|HGNC:HGNC:17976} |
|---|---|
| Function | Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I (By similarity). Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis (PubMed:12490704). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:32669547). The male germ cell-specific ribosome displays a ribosomal polypeptide exit tunnel of distinct size and charge states compared with the classical ribosome (By similarity). It is responsible for regulating the biosynthesis and folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm (By similarity). |
| Cellular Location | Cytoplasm |
| Tissue Location | Almost testis-specific (PubMed:12490704, PubMed:19333399, PubMed:28502657). Also expressed in pre- and postmenopausal ovary (PubMed:19333399). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. This gene is intronless.
References
Balasubramanian, S., et al. Genome Biol. 10 (1), R2 (2009) :
Uechi, T., et al. Nucleic Acids Res. 30(24):5369-5375(2002)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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