|Application ||WB, E|
|Other Accession||Q4VAA7, NP_695003.1|
|Calculated MW||65265 Da|
|Antigen Region||389-416 aa|
|Other Names||Sorting nexin-33, SH3 and PX domain-containing protein 3, SNX33, SH3PX3, SH3PXD3C, SNX30|
|Target/Specificity||This SNX33 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-416 amino acids from the C-terminal region of human SNX33.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SNX33 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||SH3PX3, SH3PXD3C, SNX30|
|Function||Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.|
|Cellular Location||Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773). Not associated with membranes (PubMed:21048941).|
|Tissue Location||Detected in heart and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
SNX33 belongs to the sorting nexin family. It contains a PX (phox homology) domain and an SH3 domain. It interacts with ADAM15.
Kleino, I., et al. J. Cell. Biochem. 108(4):877-885(2009)
Zhang, J., et al. J. Biol. Chem. 284(32):21659-21669(2009)
Voss, M., et al. BMC Immunol. 10, 53 (2009) :
Heiseke, A., et al. Traffic 9(7):1116-1129(2008)
Schobel, S., et al. J. Biol. Chem. 283(21):14257-14268(2008)
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