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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   SPO11 Antibody (C-term)   

SPO11 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SPO11 Antibody (C-term) AP17609b
    SPO11 Antibody (C-term) (Cat. #AP17609b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SPO11 antibody detected the SPO11 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y5K1
Other Accession NP_937998.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 44537 Da
Antigen Region 299-326 aa
Additional Information
Gene ID 23626
Other Names Meiotic recombination protein SPO11, Cancer/testis antigen 35, CT35, SPO11
Target/Specificity This SPO11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-326 amino acids from the C-terminal region of human SPO11.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSPO11 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPO11
Function Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity).
Cellular Location Nucleus.
Tissue Location Highly expressed in testis.
Research Areas
Citations (0)

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Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)
Mandon-Pepin, B., et al. Eur. J. Endocrinol. 158(1):107-115(2008)
Christensen, G.L., et al. Fertil. Steril. 84(3):758-760(2005)
Deloukas, P., et al. Nature 414(6866):865-871(2001)

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$ 295.00
$ 99.00
Cat# AP17609b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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