|Application ||WB, E|
|Calculated MW||223097 Da|
|Antigen Region||185-211 aa|
|Other Names||Myosin-7, Myosin heavy chain 7, Myosin heavy chain slow isoform, MyHC-slow, Myosin heavy chain, cardiac muscle beta isoform, MyHC-beta, MYH7, MYHCB|
|Target/Specificity||This MYH7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-211 amino acids from the N-terminal region of human MYH7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MYH7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm, myofibril. Note=Thick filaments of the myofibrils|
|Tissue Location||Both wild type and variant Gln-403 are detected in skeletal muscle (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.
Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :
Eijgelsheim, M., et al. Hum. Mol. Genet. 19(19):3885-3894(2010)
Millat, G., et al. Eur J Med Genet 53(5):261-267(2010)
Muelas, N., et al. Neurology 75(8):732-741(2010)
Zheng, D.D., et al. J. Int. Med. Res. 38(3):810-820(2010)
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