|Application ||WB, E|
|Calculated MW||40778 Da|
|Antigen Region||4-33 aa|
|Other Names||HAUS augmin-like complex subunit 7, 26S proteasome-associated UCH37-interacting protein 1, UCHL5-interacting protein, X-linked protein STS1769, HAUS7, UCHL5IP, UIP1|
|Target/Specificity||This HAUS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the N-terminal region of human HAUS7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HAUS7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.|
|Tissue Location||Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein identified by interaction with ubiquitin C-terminal hydrolase 37, which functions to edit polyubiquitin chains on ubiquitinated substrates. This protein is a subunit of the multisubunit augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis.
Xin, X., et al. Genome Res. 19(7):1262-1269(2009)
Lawo, S., et al. Curr. Biol. 19(10):816-826(2009)
Uehara, R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(17):6998-7003(2009)
Chen, M.J., et al. Nucleic Acids Res. 35(8):2682-2694(2007)
Hahn, Y., et al. Hum. Genet. 119 (1-2), 169-178 (2006) :
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