|Application ||WB, E|
|Calculated MW||49001 Da|
|Antigen Region||405-433 aa|
|Other Names||ATP-sensitive inward rectifier potassium channel 12, Inward rectifier K(+) channel Kir22, IRK-2, Inward rectifier K(+) channel Kir22v, Potassium channel, inwardly rectifying subfamily J member 12, KCNJ12, IRK2, KCNJN1|
|Target/Specificity||This KCNJ12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 405-433 amino acids from the C-terminal region of human KCNJ12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNJ12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17.
Collins, A., et al. J. Cell. Physiol. 219(1):8-13(2009)
Ji, W., et al. Nat. Genet. 40(5):592-599(2008)
Panama, B.K., et al. J. Physiol. (Lond.) 571 (PT 2), 287-302 (2006) :
Kiesecker, C., et al. J. Mol. Med. 84(1):46-56(2006)
Kubo, Y., et al. Pharmacol. Rev. 57(4):509-526(2005)
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