|Application ||WB, E|
|Other Accession||O08949, Q99PM3, NP_963889.1, NP_056943.1|
|Calculated MW||41514 Da|
|Antigen Region||297-326 aa|
|Other Names||Transcription initiation factor IIA subunit 1, General transcription factor IIA subunit 1, TFIIAL, Transcription initiation factor TFIIA 42 kDa subunit, TFIIA-42, Transcription initiation factor IIA alpha chain, TFIIA p35 subunit, Transcription initiation factor IIA beta chain, TFIIA p19 subunit, GTF2A1, TF2A1|
|Target/Specificity||This GTF2A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 297-326 amino acids from the C-terminal region of human GTF2A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GTF2A1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.|
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Provided below are standard protocols that you may find useful for product applications.
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.
Huang, Y.W., et al. Oncol. Rep. 22(4):853-861(2009)
Vega, A., et al. Gynecol. Oncol. 112(1):210-214(2009)
Hieb, A.R., et al. J. Mol. Biol. 372(3):619-632(2007)
Lee, K.A., et al. Cytokine 38(2):96-100(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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