INF2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q27J81 |
Other Accession | NP_001026884.3 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 135624 Da |
Antigen Region | 589-616 aa |
Gene ID | 64423 |
---|---|
Other Names | Inverted formin-2, HBEBP2-binding protein C, INF2, C14orf151, C14orf173 |
Target/Specificity | This INF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-616 amino acids from the Central region of human INF2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | INF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | INF2 |
---|---|
Synonyms | C14orf151, C14orf173 |
Function | Severs actin filaments and accelerates their polymerization and depolymerization. |
Cellular Location | Cytoplasm, perinuclear region |
Tissue Location | Widely expressed. In the kidney, expression is apparent in podocytes and some tubule cells |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.
References
Brown, E.J., et al. Nat. Genet. 42(1):72-76(2010)
Chhabra, E.S., et al. J. Biol. Chem. 281(36):26754-26767(2006)
Bindschadler, M., et al. Proc. Natl. Acad. Sci. U.S.A. 101(41):14685-14686(2004)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.