|Application ||WB, E|
|Calculated MW||135624 Da|
|Antigen Region||589-616 aa|
|Other Names||Inverted formin-2, HBEBP2-binding protein C, INF2, C14orf151, C14orf173|
|Target/Specificity||This INF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-616 amino acids from the Central region of human INF2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||INF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Severs actin filaments and accelerates their polymerization and depolymerization.|
|Cellular Location||Cytoplasm, perinuclear region|
|Tissue Location||Widely expressed. In the kidney, expression is apparent in podocytes and some tubule cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.
Brown, E.J., et al. Nat. Genet. 42(1):72-76(2010)
Chhabra, E.S., et al. J. Biol. Chem. 281(36):26754-26767(2006)
Bindschadler, M., et al. Proc. Natl. Acad. Sci. U.S.A. 101(41):14685-14686(2004)
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