|Application ||WB, E|
|Other Accession||P60905, P60904, Q29455, NP_079495.1|
|Calculated MW||22149 Da|
|Antigen Region||52-80 aa|
|Other Names||DnaJ homolog subfamily C member 5, Cysteine string protein, CSP, DNAJC5, CSP|
|Target/Specificity||This DNAJC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-80 amino acids from the Central region of human DNAJC5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DNAJC5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).|
|Cellular Location||Membrane; Lipid-anchor. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8.
Johnson, J.N., et al. Biochem. Cell Biol. 88(2):157-165(2010)
Schmidt, B.Z., et al. J. Biol. Chem. 284(7):4168-4178(2009)
Greaves, J., et al. J. Biol. Chem. 283(36):25014-25026(2008)
Park, J., et al. Am. J. Respir. Cell Mol. Biol. 39(1):68-76(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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