|Application ||WB, E|
|Calculated MW||46145 Da|
|Antigen Region||375-401 aa|
|Other Names||Serpin I2, Myoepithelium-derived serine protease inhibitor, Pancpin, Pancreas-specific protein TSA2004, Peptidase inhibitor 14, PI-14, SERPINI2, MEPI, PI14|
|Target/Specificity||This SERPINI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 375-401 amino acids from the C-terminal region of human SERPINI2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SERPINI2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed in pancreas and adipose tissues.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Lim, J., et al. Cell 125(4):801-814(2006)
Chang, W.S., et al. Genes Chromosomes Cancer 29(3):240-255(2000)
Xiao, G., et al. Proc. Natl. Acad. Sci. U.S.A. 96(7):3700-3705(1999)
Ozaki, K., et al. Genes Chromosomes Cancer 22(3):179-185(1998)
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