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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   ZFP36L2 Antibody (Center)   

ZFP36L2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ZFP36L2 Antibody (Center) AP17671C
    ZFP36L2 Antibody (Center) (Cat. #AP17671c) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the ZFP36L2 antibody detected the ZFP36L2 protein (arrow).
  • WB - ZFP36L2 Antibody (Center) AP17671C
    ZFP36L2 Antibody (Center) (Cat. #AP17671c) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the ZFP36L2 antibody detected the ZFP36L2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P47974
Other Accession P23949, Q805B4, Q7ZXW9, P17431, P23950, Q07352, NP_008818.3
Reactivity Human, Mouse
Predicted Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51063 Da
Antigen Region 166-193 aa
Additional Information
Gene ID 678
Other Names Zinc finger protein 36, C3H1 type-like 2, ZFP36-like 2, Butyrate response factor 2, EGF-response factor 2, ERF-2, Protein TIS11D, ZFP36L2, BRF2, ERF2, RNF162C, TIS11D
Target/Specificity This ZFP36L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-193 amino acids from the Central region of human ZFP36L2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZFP36L2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZFP36L2
Synonyms BRF2, ERF2, RNF162C, TIS11D
Function mRNA-binding protein that plays a key role in self- renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit- erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Research Areas
Citations (0)

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This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors.


Morgan, B.R., et al. Protein Sci. 19(6):1222-1234(2010)
Jackson, R.S. II, et al. Cell Cycle 5(24):2889-2893(2006)
Hudson, B.P., et al. Nat. Struct. Mol. Biol. 11(3):257-264(2004)
Blackshear, P.J., et al. Prog. Nucleic Acid Res. Mol. Biol. 75, 43-68 (2003) :
Ino, T., et al. Oncogene 11(12):2705-2710(1995)

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$ 295.00
$ 99.00
Cat# AP17671C
(40 western blots)
Availability: In Stock
Bulk Size
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