|Application ||WB, E|
|Other Accession||Q8C5Q4, NP_002083.3|
|Calculated MW||53126 Da|
|Antigen Region||307-333 aa|
|Other Names||G-rich sequence factor 1, GRSF-1, GRSF1|
|Target/Specificity||This GRSF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-333 amino acids from the Central region of human GRSF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GRSF1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences.|
|Cellular Location||Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene.
Kash, J.C., et al. J. Virol. 76(20):10417-10426(2002)
Park, Y.W., et al. Proc. Natl. Acad. Sci. U.S.A. 96(12):6694-6699(1999)
Banga, S.S., et al. Cytogenet. Cell Genet. 73(4):295-296(1996)
Qian, Z., et al. Nucleic Acids Res. 22(12):2334-2343(1994)
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